Parameter | Description | Unit |
---|---|---|
Mean platelet volume (MPV) | Analyser-calculated measure of thrombocyte volume | femtoliters (fL) |
Platelet volume distribution width (PDW) | Indicator of volume variability in platelets size | percentage (%) |
Plateletcrit (PCT) | Volume occupied by platelets in the blood | percentage (%) |
Mean platelet component (MPC) | Measure of mean refractive index of the platelets | gram/decilitre (g/dL) |
Mean platelet mass (MPM) | MPM is calculated from the platelet dry mass histogram | picogram (pg) |
Platelet component distribution width (PCDW) | Measure of the variation in platelet shape | gram/decilitre (g/dL) |
Platelet larger cell ratio (P-LCR) | Indicator of larger (> 12 fL) circulating platelets | percentage (%) |
Immature platelet fraction (IPF) | Percentage of immature platelets | percentage (%) |
Reference (publication year) | Number of patients and controls (years) | Sample, analyzer, method | Platelet indices | P | Study design | Comment | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patients | Controls | |||||||||||||
Acute Appendicitis (adults) | ||||||||||||||
Albayrak et al. (2011) | 226 patients with AA (2.5 ± 15.1) and 206 controls (35.5 ± 14.7) | ND, Beckman Coulter analyzer, impedance | MPV: 7.25 ± 0.85 fL | MPV: 9.01 ± 1.33 fL | Decreased* (P < 0.001) | Diagnostic, case-control, prospective | CBC analysed within 2 hours after collection. Best cut-off point for MPV in the diagnosis of AA was ≤ 7.6 fL. | |||||||
Tanrikulu et al. (2014) | 239 patients with AA and 21 patients with normal appendix were included jointly in the patient group (31.8 ± 12.4); 158 controls (32.2 ± 10.5) | ND | MPV: 7.75 ± 1.24 fL | MPV: 8.49 ± 0.97 fL | Decreased* (P < 0.001) | Diagnostic, case-control, retrospective, multicenter study | Best cut-off point for MPV in the diagnosis of AA was ≤ 7.3 fL. | |||||||
Erdem et al. (2015) | 100 patients with AA (33.6 ± 12.2) and 100 controls (30.8 ± 9.7) | ND | MPV: 7.4 ± 0.9 fL | MPV: 9.1 ± 1.6 fL | Decreased* (P < 0.001) | Diagnostic, case-control, retrospective | CBCs analysed 24 hours prior to surgery. Best cut-off point for MPV in the diagnosis of AA was ≤ 7.95 fL. | |||||||
Dinc et al. (2015) | 295 patients with AA and 100 patients with other intra-abdominal infections; 100 controls (16–94) | EDTA-anticoagulated blood, ND | MPV (fL) in AA patients 8.5 (6.1–14.2); MPV (fL) in patients with intra-abdominal infection 8.9 (6.0–13); PDW (%) in AA patients 18.4 (10.3–62.5); PDW (%) in patients in intra-abdominal infection 40.8 (12.8–87.9) | MPV: 8.9 (6.9–14.5) fL; PDW 49.0 (10.6 -86.5)% | MPV decreased* (P = 0.001); PDW increased† (P < 0.001) | Diagnostic, case-control, retrospective | All samples analysed within 10 minutes. Diagnostic accuracy for PDW was 96.0%. | |||||||
Yang et al. (2014) | 196 AA patients (41.8 ± 15.5) and 143 controls (44.0 ± 10.3) | EDTA-anticoagulated blood, Advia 2120 (Siemens Healthcare Diagnostics, Germany), optical method | MPV: 7.82 ± 0.64 fL | MPV: 7.96 ± 0.58 fL | Decreased* (P = 0.042) | Diagnostic, case-control, retrospective | CBC analysed within 2 hours after collection. | |||||||
Reference (publication year) | Number of patients and controls (years) | Sample, analyzer, method | Platelet indices | P | Study design | Comment | ||||||||
Patients | Controls | |||||||||||||
Fan et al. (2015) | 160 gangrenous AA patients (43.0 ± 12.5) and 160 healthy controls (45.6 ± 19.6) | EDTA-anticoagulated blood, ND | MPV: 9.21 ± 1.38 fL; PDW: 15.25 ± 1.90% | MPV: 10.91 ± 2.72 fL; PDW: 12.5 ± 1.93% | MPV decreased* (P = 0.000); PDW increased† (P = 0.000) | Diagnostic, case-control, retrospective | All samples analysed within 10 minutes. Best cut-off point for MPV in the diagnosis of AA was ≤ 9.6fL. Best cut-off point for PDW in the diagnosis of AA was ≥ 15.1fL. | |||||||
Narci et al. (2013) | 503 patients (34.7 ± 14.1) and 121 controls (35.2 ± 8.1) | Cell-Dyne 3700 (Abbott Diagnostics, IL, USA), impedance | MPV: 7.92 ± 1.68 fL | MPV: 7.43 ± 1.34 fL | Increased† (P < 0.001) | Diagnostic, case-control, retrospective | Best cut-off point for MPV in the diagnosis of AA was ≥ 7.87 fL | |||||||
Bozkurt et al. (2015) | Patients operated for appendectomy were divided into three groups: 90 uncomplicated AA; 120 complicated AA and 65 negative appendectomy (17–78) | Sysmex XT-2000i (Sysmex Corporation, Kobe, Japan), impedance and optic | MPV in uncomplicated AA patients 10.40 ± 0.93 fL; MPV in complicated AA 10.27 ± 0.93 fL; MPV in negative appendectomy patients 10.42 ± 1.00 fL | None | Not changed (P =0.478) | Diagnostic, case-control, retrospective | Best cut-off point for MPV in the diagnosis of AA was ≥ 10.8 fL. | |||||||
Lee et al. (2011) | 130 female AA patients (43.4 ± 16.6) and 85 female controls (45.1 ± 12.1) | ND | MPV: 10.58 ± 0.80 fL | MPV: 10.04 ± 0.83 fL | Not changed (P = 0.285) | Diagnostic, case-control, retrospective | - | |||||||
Kucuk et al. (2015) | 60 patients (33.15 ± 10.94) | Cell-Dyne 3700 (Abbott Diagnostics, IL, USA), impedance | MPV: in AA patients 7.03 ± 0.8 fL; previous MPV: 7.58 ± 1.11 fL | None | Decreased* (P = 0.01) | Diagnostic, case-series, retrospective | Previous MPV of the same patient was evaluated as control. | |||||||
Kılıç et al. (2015) | 316 AA patients and 316 controls (14–76) | EDTA-anticoagulated blood, LH 780 Analyzer (Beckman Coulter Inc., USA), impedance | MPV: 8.03 (5.53–14.40) fL | MPV: 8.10 (5.70–13.90) fL | Not changed (P = 0.193) | Diagnostic, case-control, retrospective | CBC analyses were performed within 2 hours after collection. | |||||||
Aktimur et al. (2015) | 407 AA patients and 61 patients with normal appendix (range 16–86) | ND | MPV in AA patients 9.6 ± 1.5 fL; MPV in negative appendectomy 9.1 ± 1.5 fL | None | Increased (P = 0.018) | Diagnostic, case-control, retrospective | For cut-off value of 9.6 fL, sensitivity was 57.1% and specificity was 60.7%. | |||||||
Reference (publication year) | Number of patients and controls (years) | Sample, analyzer, method | Platelet indices | P | Study design | Comment | ||||||||
Patients | Controls | |||||||||||||
Sexana D et al. (2015) | Attempted to define potential thresholds value which is predictive of a diagnosis in 213 AA patients. | ND | ND | None | Diagnostic retrospective | When they used an MPV cut-off value of ≤ 7.6 fL, they found sensitivity, specificity and accuracy of which was 83.73%, 75% and 83.56%, respectively | ||||||||
Acute appendicitis (pediatric) | ||||||||||||||
Bilici S et al. (2011) | 100 AA patients (8.1 ± 3.4) and 100 controls (8.7 ± 3.6) | EDTA-anticoagulated blood, ABX-Pentra DX 120 (ABX-Horiba, France), impedance | MPV: 7.55 ± 0.89 fL | MPV: 8.90 ± 1.29 fL | Decreased* (P = 0.001) | Diagnostic, case-control, retrospective | CBC was analyzed 2 hours after blood collection. Specificity was 54% and sensitivity was 87% for MPV at ≤ 7.4 fL. | |||||||
Uyanik et al. (2012) | 305 AA patients (9.5 ± 2.9) and 305 controls (9.6 ± 3.1) | EDTA-anticoagulated blood, ND | MPV: 7.9 ± 0.9 fL | MPV: 7.7 ± 0.8 fL | Not changed (P > 0.05) | Diagnostic, case-control, retrospective | CBC analyses were performed within 1 hour after collection. | |||||||
Yilmaz et al. (2015) | 204 AA patients (10.4 ± 3.7) and 20 subjects with normal appendix vermiformis (10.9 ± 4.2) | EDTA-anticoagulated blood, Mindray BC-5800 (Mindray BioMedical Electronics Co., Ltd., China), iImpedance | MPV in AA patients 7.37 ± 0.9 fL; MPV in negative appendectomy 7.60 ± 1.24 fL; PCT in AA patients 0.220 ± 0.057; PCT in negative appendectomy 0.208 ± 0.045; PDW in AA patients 16.3 ± 0.5; PDW in negative appendectomy 16.4 ± 0.7 | None | Not changed (P > 0.05) for MPV, PCT and PDW | Diagnostic, case-control | The number of patients with normal appendix vermiformis was too small. | |||||||
Acute cholecystitis | ||||||||||||||
Seker et al. (2013) | 33 patients with AC (56.4 ± 15.7), 32 patients with CC (51.4 ± 13.8), 28 controls (54.7 ± 9.61) | ND | MPV in AC patients 6.38 ± 0.88 fL; MPV in CC patients 7.78 ± 0.75 fL | MPV: 7.88 ± 0.74 fL | Decreased* (P < 0.05) | Case-control Retrospective | The number of patients was too small. | |||||||
Reference (publication year) | Number of patients and controls (years) | Sample, analyzer, method | Platelet indices | P | Study design | Comment | ||||||||
Patients | Controls | |||||||||||||
Acute mesenteric ischemia (AMI) | ||||||||||||||
Türkoğlu et al. (2015) | 95 patients who underwent emergency surgery for acute mesenteric ischemia (68.4 ± 14.4) and 90 controls (67.1 ± 15.7) | EDTA-anticoagulated blood, Cell-Dyne 3700 (Abbott Diagnostics,IL, USA), impedance | MPV: 9.4 ± 1.1 fL | MPV: 7.4 ± 1.4 fL | (P < 0.001) | Case-control Retrospective | The best cut-off point for MPV in the diagnosis of AA was > 8.1 fL | |||||||
Altıntoprak et al. (2013) | 30 patients operated for AMI (29–94), two groups according to outcome – non-survivors (group 1) and survivors (group 2) | ND | MPV in non-survivors: 9.01 fL; MPV in survivors: 7.80 fL | None | (P = 0.002) | Prognostic, retrospective | SDs were not given | |||||||
Aktimur et al (2015) | 62 AMI related laparotomy and/or bowel resection patients (41–93 yrs), 62 AA patients (14–86), 61 negative appendectomy patients (16–73) | ND | MPV in AMI patients 10.8 ± 0.9 fL; MPV in AA patients 10.5 ± 0.8 fL; MPV in negative appendectomy patients 9.1 ± 1.5 fL | None | (P < 0.001) | Retrospective | The median ages were significantly different. CBCs were taken 24 hours prior to surgery. | |||||||
Bilgiç et al. (2015) | 61 patients operated for AMI (40–91); two groups according to outcome: Survivors (53–87) and non-survivors (40–91) | ND | Non-survivor MPV: 8.4 (5.5 –10.4) fL; survivor MPV: 7.6 (6.6–8.9) fL | None | (P < 0.01) | Prognostic, retrospective | Cut-off point for mortality in AMI was MPV = 8.1 fL. Sensitivity, specificity, positive and negative predictive values were 60%, 73.1%, 74.7%, and 58%, respectively. | |||||||
Age is presented as mean age ± standard deviation or age range. Platelet indices are presented as mean ± standard deviation or mean (range). AA – acute appendicitis; MPV – mean platelet volume; CC – chronic cholecystitis; AMI – acute mesenteric ischemia; CBC – complete blood count; ND – not declared; decreased * – decreased compared to healthy controls; increased † – increased compared to healthy controls. |